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A new cytotoxic 1-azaanthraquinone from the stems of Goniothalamus laoticus

2012-09-12 1173

A new cytotoxic 1-azaanthraquinone from the stems of Goniothalamus laoticus

A new 1-azaanthraquinone, named laoticuzanone A (1), and a synthetically known 3-methyl- 1H-1-azaanthracene-2,9,10-trione (2), together with four known compounds, Griffithazanone A (3), methyl sinapate (4), methyl p-coumarate (5), and p-hydroxyphenylethyl p-coumarate (6) were isolated from the stems of Goniothalamus laoticus. Their structures were established on the basis of spectroscopic data as well as comparisons with the previous literature data. Compound 1 showed the highest cytotoxicity against KB and HeLa cells with IC50 values of 0.68 and 0.50 ?g/ml, respectively.

Authors : Santi Tip-pyang,Yawistha Limpipatwattana,Suttira Khumkratok,Pongpan Siripong,Jirapast Sichaem
Book /Journal Title : Fitoterapia ;2010 / 81 / 894-896

 

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